The hormone aldosterone, which prevents dehydration in our bodies, has been linked to worsening kidney disease. This conclusion was made by scientists from Boston University.
A powerful drug used to slow the progression of kidney and cardiovascular disease in people with type 2 diabetes may also help kidney disease without diabetes. The key target of this drug is the hormone aldosterone produced by the adrenal glands. In an observational study, the authors analyzed the health data of 3,680 people with chronic kidney disease over 10 years.
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It was found that people with elevated levels of aldosterone – a key hormone that preserves the salt processed by the adrenal glands – had a higher risk of progression of severe kidney disease during the observation period. They were more likely to lose half of their kidney function, leading to hemodialysis or even end-stage renal disease. At the same time, elevated aldosterone levels are very common in the population, but they are often overlooked even by individuals at high risk of developing kidney failure.
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Studies evaluated the effects of finerenone, a non-hysteroid drug approved in the US for people with type 2 diabetes and chronic kidney disease. The researchers believe that finerenone may also help prevent or worsen kidney disease in people without diabetes, reducing the risk of dangerously high potassium levels, compared to conventional drugs for this purpose, such as spironolactone or eplerenone. (READ MORE) 
Boston University
Medicine
a private research university located in Boston, Massachusetts, USA. Founded in 1839. The second largest research university in the country