A study has shown that the loss of the Y chromosome in men's white blood cells can cause heart fibrosis, heart failure and death from cardiovascular disease. This conclusion was made by scientists at Uppsala University in Sweden.
Until recently, science did not know about the existence of a link between the loss of the Y chromosome and cardiovascular pathologies. However, previous studies have found that men with mosaic Y chromosome loss (mLOY) in their blood have an increased risk of age-related diseases such as dementia and cancer. A new study established a causal relationship when its authors used the CRISPR gene editor to generate lab mice with mLOY in their white blood cells.
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This loss has been found to cause direct damage to the animal's organs, and such mice have a shorter lifespan. In laboratory models, mLOY has been shown to have a direct effect on negative cardiac and vascular outcomes in mice. In particular, the heart muscle underwent more extensive scarring, known as fibrosis.
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The authors of the study were also able to test the observed effect in mice in human epidemiological studies. It has been established that mLOY is a new significant risk factor for mortality from cardiovascular diseases among men. And men with mLOY blood levels at baseline had a 30% increased risk of death from heart failure and other types of heart disease during the 11 years of follow-up. (READ MORE) 
Uppsala University
Medicine
the oldest university in Sweden and throughout Scandinavia, founded in 1477, located in the Swedish city of Uppsala