Scientists believe that repeated administration of the drug can reverse memory loss in older people.
Researchers have found that an existing drug used to treat HIV patients could hold the key to creating a cure.
“The study showed that maraviroc is able to cleanse the brain of false proteins that are associated with the development of dementia. According to scientists, by clearing these proteins, it prevents dangerous accumulation and slows down the progression of the disease,” says neurologist Alexandra Alekhina, especially for Medikforum.<
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Not only have scientists discovered a new mechanism for how our microglia accelerate neurodegeneration, we have also shown that it can be interrupted, potentially even with existing safe treatments.
The brain and central nervous system have their own specialized immune cells known like microglia, which are supposed to protect against unwanted and toxic materials. In dementia, they begin to act, but in a way that disrupts the process of autophagy – the process by which cells decompose and recycle their components.
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This causes a chemical called tau to clump together, destroying brain cells.
“Microglia start releasing these chemicals long before there are any physical signs of the disease. This suggests, as we would expect, that if we are going to find effective treatments for diseases like Huntington's disease and dementia, these treatments will need to be started before the person starts showing symptoms.”
The team tested the mice. , which have been genetically modified to develop forms of dementia characterized by tau accumulation. When the effects of CCR5 were knocked out, the animals were protected.
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