Researchers at the University of Washington (UW) in Seattle have developed a toothpaste that could provide permanent treatment for hyperesthesia (dental sensitivity).
The lozenge uses a peptide derived from a larger protein called amelogenin, which plays a key role in the biological development of human teeth, explained professor of restorative dentistry , Dr. Sami Dogan. The specially designed peptide, called sADP5, “captures” calcium and phosphate ions, the main mineral components of teeth, and uses them to create new mineral microlayers, he says.
Deniz T. Yuchesoy, PhD, who once came up with the idea for the lozenge, added: “Our technology forms the same minerals that are found in teeth, including enamel, cementum and dentin, which are dissolved by demineralization and cause sensitivity. The newly formed mineral microlayers close the channels of communication with the dental nerves, and then hypersensitivity ceases to be a problem. ”
Ultimately, the peptide could be integrated into virtually any type of oral care product, the research team noted. In preclinical trials, participants received a cough lozenge-sized toothpaste that contained a calcium and phosphate core coated with a layer of peptide-based flavor. Researchers have also developed peptide-based formulations, including mouthwashes, tooth gels, tooth whiteners, and toothpaste.